Journal: PLoS ONE

Article Title: An Integrated Genomic and Expression Analysis of 7q Deletion in Splenic Marginal Zone Lymphoma

doi: 10.1371/journal.pone.0044997

Figure Lengend Snippet: CGH using the chromosome 7 (Ch7) BAC tile-path array, Agilent 244A oligonucleotide array platform and chromosome 7 gene resolution oligonucleotide array maps the MDR to a 2.8 Mb region at 7q32 (Panel A). As shown by Affymetrix gene expression analyses, the genes on 7q, particularly those within the MDR are significantly under-expressed in SMZL with 7q deletion than those without the deletion. Panel B shows the genes significantly differentially expressed between SMZL with and without 7q deletion according to P values, while Panel C displays those with further fold change more than 1.25×SD (standard deviation).

Article Snippet: To further investigate the possible existence of cryptic homozygous deletions that might have been under-detected by the above BAC tile-path and standard Agilent oligonucleotide array CGH, we investigated 21 cases of SMZL including 7 with 7q deletion using a customised oligonucleotide array with a 2 Kb resolution covering the whole chromosome 7q and gene resolution in the MDR.

Techniques: Expressing, Standard Deviation